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ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries

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2012
460.pdf (840.4Kb)
Authors
Filipović, Nenad
Rosić, Mirko
Tanasković, Irena
Milošević, Žarko
Nikolić, Dalibor
Zdravković, Nebojša
Peulić, Aleksandar
Kojić, Milos R.
Fotiadis, Dimitris I.
Parodi, Oberdan
Article (Published version)
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Abstract
Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.
Keywords:
Atherosclerosis / low-density lipoprotein (LDL) / plaque / wall shear stress
Source:
IEEE Transactions on Information Technology In Biomedicine, 2012, 16, 2, 272-278
Publisher:
  • IEEE -Inst Electrical Electronics Engineers Inc, Piscataway
Funding / projects:
  • Multi-level patient-specific artery and atherogenesis modelfor outcome prediction, decision support treatment, andvirtual hand-on training (EU-224297)
  • Application of biomedical engineering for preclinical and clinical practice (RS-41007)
  • Multiscale Methods and Their Applicatios in Nanomedicine (RS-174028)

DOI: 10.1109/TITB.2011.2168418

ISSN: 1089-7771

PubMed: 21937352

WoS: 000304158600013

Scopus: 2-s2.0-84858113550
[ Google Scholar ]
31
30
URI
https://gery.gef.bg.ac.rs/handle/123456789/462
Collections
  • Radovi istraživača
Institution/Community
Geografski fakultet
TY  - JOUR
AU  - Filipović, Nenad
AU  - Rosić, Mirko
AU  - Tanasković, Irena
AU  - Milošević, Žarko
AU  - Nikolić, Dalibor
AU  - Zdravković, Nebojša
AU  - Peulić, Aleksandar
AU  - Kojić, Milos R.
AU  - Fotiadis, Dimitris I.
AU  - Parodi, Oberdan
PY  - 2012
UR  - https://gery.gef.bg.ac.rs/handle/123456789/462
AB  - Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.
PB  - IEEE -Inst Electrical Electronics Engineers Inc, Piscataway
T2  - IEEE Transactions on Information Technology In Biomedicine
T1  - ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries
VL  - 16
IS  - 2
SP  - 272
EP  - 278
DO  - 10.1109/TITB.2011.2168418
UR  - conv_1500
ER  - 
@article{
author = "Filipović, Nenad and Rosić, Mirko and Tanasković, Irena and Milošević, Žarko and Nikolić, Dalibor and Zdravković, Nebojša and Peulić, Aleksandar and Kojić, Milos R. and Fotiadis, Dimitris I. and Parodi, Oberdan",
year = "2012",
abstract = "Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.",
publisher = "IEEE -Inst Electrical Electronics Engineers Inc, Piscataway",
journal = "IEEE Transactions on Information Technology In Biomedicine",
title = "ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries",
volume = "16",
number = "2",
pages = "272-278",
doi = "10.1109/TITB.2011.2168418",
url = "conv_1500"
}
Filipović, N., Rosić, M., Tanasković, I., Milošević, Ž., Nikolić, D., Zdravković, N., Peulić, A., Kojić, M. R., Fotiadis, D. I.,& Parodi, O.. (2012). ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries. in IEEE Transactions on Information Technology In Biomedicine
IEEE -Inst Electrical Electronics Engineers Inc, Piscataway., 16(2), 272-278.
https://doi.org/10.1109/TITB.2011.2168418
conv_1500
Filipović N, Rosić M, Tanasković I, Milošević Ž, Nikolić D, Zdravković N, Peulić A, Kojić MR, Fotiadis DI, Parodi O. ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries. in IEEE Transactions on Information Technology In Biomedicine. 2012;16(2):272-278.
doi:10.1109/TITB.2011.2168418
conv_1500 .
Filipović, Nenad, Rosić, Mirko, Tanasković, Irena, Milošević, Žarko, Nikolić, Dalibor, Zdravković, Nebojša, Peulić, Aleksandar, Kojić, Milos R., Fotiadis, Dimitris I., Parodi, Oberdan, "ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries" in IEEE Transactions on Information Technology In Biomedicine, 16, no. 2 (2012):272-278,
https://doi.org/10.1109/TITB.2011.2168418 .,
conv_1500 .

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