Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.
TY - JOUR
AU - Filipović, Nenad
AU - Rosić, Mirko
AU - Tanasković, Irena
AU - Milošević, Žarko
AU - Nikolić, Dalibor
AU - Zdravković, Nebojša
AU - Peulić, Aleksandar
AU - Kojić, Milos R.
AU - Fotiadis, Dimitris I.
AU - Parodi, Oberdan
PY - 2012
UR - https://gery.gef.bg.ac.rs/handle/123456789/462
AB - Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.
PB - IEEE -Inst Electrical Electronics Engineers Inc, Piscataway
T2 - IEEE Transactions on Information Technology In Biomedicine
T1 - ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries
VL - 16
IS - 2
SP - 272
EP - 278
DO - 10.1109/TITB.2011.2168418
UR - https://hdl.handle.net/21.15107/rcub_gery_462
ER -
@article{
author = "Filipović, Nenad and Rosić, Mirko and Tanasković, Irena and Milošević, Žarko and Nikolić, Dalibor and Zdravković, Nebojša and Peulić, Aleksandar and Kojić, Milos R. and Fotiadis, Dimitris I. and Parodi, Oberdan",
year = "2012",
abstract = "Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.",
publisher = "IEEE -Inst Electrical Electronics Engineers Inc, Piscataway",
journal = "IEEE Transactions on Information Technology In Biomedicine",
title = "ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries",
volume = "16",
number = "2",
pages = "272-278",
doi = "10.1109/TITB.2011.2168418",
url = "https://hdl.handle.net/21.15107/rcub_gery_462"
}
Filipović, N., Rosić, M., Tanasković, I., Milošević, Ž., Nikolić, D., Zdravković, N., Peulić, A., Kojić, M. R., Fotiadis, D. I.,& Parodi, O.. (2012). ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries. in IEEE Transactions on Information Technology In Biomedicine
IEEE -Inst Electrical Electronics Engineers Inc, Piscataway., 16(2), 272-278.
https://doi.org/10.1109/TITB.2011.2168418
https://hdl.handle.net/21.15107/rcub_gery_462
Filipović N, Rosić M, Tanasković I, Milošević Ž, Nikolić D, Zdravković N, Peulić A, Kojić MR, Fotiadis DI, Parodi O. ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries. in IEEE Transactions on Information Technology In Biomedicine. 2012;16(2):272-278.
doi:10.1109/TITB.2011.2168418
https://hdl.handle.net/21.15107/rcub_gery_462 .
Filipović, Nenad, Rosić, Mirko, Tanasković, Irena, Milošević, Žarko, Nikolić, Dalibor, Zdravković, Nebojša, Peulić, Aleksandar, Kojić, Milos R., Fotiadis, Dimitris I., Parodi, Oberdan, "ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries" in IEEE Transactions on Information Technology In Biomedicine, 16, no. 2 (2012):272-278,
https://doi.org/10.1109/TITB.2011.2168418 .,
https://hdl.handle.net/21.15107/rcub_gery_462 .
