ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries

2012
Authors
Filipović, Nenad
Rosić, Mirko

Tanasković, Irena

Milošević, Žarko
Nikolić, Dalibor

Zdravković, Nebojša

Peulić, Aleksandar

Kojić, Milos R.
Fotiadis, Dimitris I.
Parodi, Oberdan
Article (Published version)

Metadata
Show full item recordAbstract
Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.
Keywords:
Atherosclerosis / low-density lipoprotein (LDL) / plaque / wall shear stressSource:
IEEE Transactions on Information Technology In Biomedicine, 2012, 16, 2, 272-278Publisher:
- IEEE -Inst Electrical Electronics Engineers Inc, Piscataway
Funding / projects:
- Multi-level patient-specific artery and atherogenesis modelfor outcome prediction, decision support treatment, andvirtual hand-on training (EU-224297)
- Application of biomedical engineering for preclinical and clinical practice (RS-41007)
- Multiscale Methods and Their Applicatios in Nanomedicine (RS-174028)
DOI: 10.1109/TITB.2011.2168418
ISSN: 1089-7771
PubMed: 21937352
WoS: 000304158600013
Scopus: 2-s2.0-84858113550
Collections
Institution/Community
Geografski fakultetTY - JOUR AU - Filipović, Nenad AU - Rosić, Mirko AU - Tanasković, Irena AU - Milošević, Žarko AU - Nikolić, Dalibor AU - Zdravković, Nebojša AU - Peulić, Aleksandar AU - Kojić, Milos R. AU - Fotiadis, Dimitris I. AU - Parodi, Oberdan PY - 2012 UR - https://gery.gef.bg.ac.rs/handle/123456789/462 AB - Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented. PB - IEEE -Inst Electrical Electronics Engineers Inc, Piscataway T2 - IEEE Transactions on Information Technology In Biomedicine T1 - ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries VL - 16 IS - 2 SP - 272 EP - 278 DO - 10.1109/TITB.2011.2168418 UR - https://hdl.handle.net/21.15107/rcub_gery_462 ER -
@article{ author = "Filipović, Nenad and Rosić, Mirko and Tanasković, Irena and Milošević, Žarko and Nikolić, Dalibor and Zdravković, Nebojša and Peulić, Aleksandar and Kojić, Milos R. and Fotiadis, Dimitris I. and Parodi, Oberdan", year = "2012", abstract = "Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.", publisher = "IEEE -Inst Electrical Electronics Engineers Inc, Piscataway", journal = "IEEE Transactions on Information Technology In Biomedicine", title = "ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries", volume = "16", number = "2", pages = "272-278", doi = "10.1109/TITB.2011.2168418", url = "https://hdl.handle.net/21.15107/rcub_gery_462" }
Filipović, N., Rosić, M., Tanasković, I., Milošević, Ž., Nikolić, D., Zdravković, N., Peulić, A., Kojić, M. R., Fotiadis, D. I.,& Parodi, O.. (2012). ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries. in IEEE Transactions on Information Technology In Biomedicine IEEE -Inst Electrical Electronics Engineers Inc, Piscataway., 16(2), 272-278. https://doi.org/10.1109/TITB.2011.2168418 https://hdl.handle.net/21.15107/rcub_gery_462
Filipović N, Rosić M, Tanasković I, Milošević Ž, Nikolić D, Zdravković N, Peulić A, Kojić MR, Fotiadis DI, Parodi O. ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries. in IEEE Transactions on Information Technology In Biomedicine. 2012;16(2):272-278. doi:10.1109/TITB.2011.2168418 https://hdl.handle.net/21.15107/rcub_gery_462 .
Filipović, Nenad, Rosić, Mirko, Tanasković, Irena, Milošević, Žarko, Nikolić, Dalibor, Zdravković, Nebojša, Peulić, Aleksandar, Kojić, Milos R., Fotiadis, Dimitris I., Parodi, Oberdan, "ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteries" in IEEE Transactions on Information Technology In Biomedicine, 16, no. 2 (2012):272-278, https://doi.org/10.1109/TITB.2011.2168418 ., https://hdl.handle.net/21.15107/rcub_gery_462 .